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In Arabidopsis thaliana , low levels of glutathione synthetase have resulted in increased vulnerability to stressors such as heavy metals, toxic organic chemicals, and oxidative stress

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7 , 593040 (2021) V

At the level of the mitochondrial inner membrane ETC, BDNF upregulates the expression of Nicotinamide adenine dinucleotide (NADH): ubiquinone oxidoreductase core subunit S1 (NDUFS1, a subunit of complex I) and cytochrome C oxidase subunit 5B (COX5B, a subunit of complex IV) via TrkB-mediated phosphorylation of cAMP-response element binding protein (CREB), restoring the activity of mitochondrial complexes I/IV in PD models [94, 95]