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If the macromolecules targeted are important parts of the cellular structure such as nucleic acids, proteins and lipids, considerable oxidative injury can occur [3]

MTHFR mutations can mean less active folate available to donate a methyl group to vitamin B12, which needs folate for the homocysteine-methionine conversion process

rebaudiana for short) is a perennial herbaceous plant belonging to the Asteraceae family, native to the Amambay Mountains of South America, and primarily distributed in Paraguay and Brazil

However, baseline homocysteine levels tend to be lower in people with Down syndrome than people without Down syndrome