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Abbreviations MASH : Metabolic dysfunction-associated steatohepatitis MASLD : Metabolic dysfunction-associated fatty liver disease HF/HFD : High-fructose/high-fat diet DMSO : Dimethylsulfoxide Mito : Mitoglitazone Pro : Proanthocyanidin ALT : Alanine aminotransferase AST : Aspartate aminotransferase sTfR1 : Soluble transferrin receptor-1 ACSL4 : Acyl-CoA synthetase long-chain family member 4 GPX4 : Glutathione peroxidase-4 GPX : Glutathione peroxidase GSH : Glutathione ROS : Reactive oxygen species LPO : Lipid peroxidation HOMA-IR : Homeostatic model assessment for insulin resistance AMPK : Adenosine monophosphate-activated protein kinase References Ameka MK, Hasty AH (2022) Paying the iron price: Liver iron homeostasis and metabolic disease

doi: 10.1016/j.freeradbiomed.2012.08.596

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Group Comparisons at Week 8 : Group 1 (topical and oral placebo) MI: 385.69 94.38 Group 2 (topical GSH, oral placebo) MI: 330.69 87.90 Group 3 (oral GSH, topical placebo) MI: 347.00 81.77 Group 4 (topical and oral GSH) MI: 314.35 70.13 P - values for Group Comparisons : Group 1 vs Group 2: P = 0