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Typically administered via a series of injections following an injury or for chronic inflammation, Traumeel has been recommended over NSAIDs for muscle strains due to concerns that NSAIDs may increase the likelihood of recurrence by masking pain

When the vitreous gel is removed surgically, it is replaced by fluid, which does not provide a comparable level of inhibition of diffusion

Some of the resulting organic acids are thought to bear a direct toxicity to mitochondria, which leads to dysfunction of high energy-demanding organs such as the heart, the optic nerve, the liver, the brain, and the hematological precursor cells

However, extensive clinical trials are needed for validation