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Lopes EF, Marques LS, Duranti RG, de Oliveira AT, Lopes RF, Rodrigues JL

143,473,481,482,483,484,485 Notably, although hypoxia might reduce energy production of OXPHOS, it alleviates Leigh syndrome in disease models by reducing mtROS generation and activating hypoxia-inducible factor pathway, 12 indicating the downstream pathways of genetic mitochondrial dysfunction are promising therapeutic targets