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Importantly, IGF1R expression also determine RCC aggressiveness, while patients with clear-cell RCC shown kidney IGF1R expression higher than 50% have shorter survival time, a difference that becomes particularly significant after two years of follow-up.40 Moreover, after adjustment for age and stage at diagnosis, those patients with renal IGF1R expression higher than 50% had a 4.2 increased risk of death compared to those with lower renal IGF1R expression

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The injections of methyl B-12 from the USA company (Vitaminquick) are at only 500 ml, which is also what the Georgian hematologist ordered though Im planning to keep on higher dose daily injections for hoping to see what or how much nerve regeneration can happen over 6 months, etc

This hypothesis can be tested in future work by investigating whether cysteine supplementation of BSO-treated mice can rescue fat gain