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In the CY 2025 PFS proposed rule, although we provided one example of a potential scenario in which this adjustment would apply (89 FR 61907), we did not discuss the potential for there to be various scenarios around the timing of when the revised initial determination is issued for a performance year relative to when the ACO enters a subsequent agreement period for which the performance year for which we issue a revised initial determination corresponds to a benchmark year (BY)

Often the medications and treatments that are used to fight chronic or life-threatening conditions, have a tendency for healthy cells to be affected, too, which may cause side effects

Individuals with a history of allergies or those requiring lifelong supplementation due to absorption disorders may be at higher risk

Fourth, the lack of prospective symptom assessment with the same questionnaires in OAB and IC/BPS patients