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doi: 10.1586/epr.10.98

E., Chang, J., Cox, T

A clinician may consider discussing MOTS-c when the bigger pattern includes: Early insulin resistance markers or metabolic syndrome risk factors Weight gain paired with fatigue, despite stable routines Training that creates soreness, but not adaptation Sleep disruption that keeps the nervous system in high alert This is where a plan should be built with guardrails

This is consistent with GHK-Cus known role in upregulating collagen synthesis in dermal fibroblasts, a mechanism confirmed in a comprehensive review in Biomolecules documenting GHK-Cus influence across more than 4,000 human genes involved in tissue remodeling and repair