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Nat Commun 15 , 4244 (2024)

110 SmithD

4.6.5 SIRT1/PGC-1 pathway The Sirtuin 1/PPAR- co-activator1 (SIRT1/PGC-1) pathway is critical in regulating mitochondrial function and OS, which are key factors in the pathogenesis of DN

During exercise, a number of researchers have assumed that the increased ROS generation that occurs during contractile activity is directly related to the elevated oxygen consumption that occurs with increased mitochondrial activity (e.g