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Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE-MTDPS1)

F.FreitasA

The fact that of all tested tissues, we identified T H 17 cells accumulating solely in Pps and dural meninges of 5xFAD mice, suggests that gut-educated CD4 + T cells may be a source of disease-associated IL-17A during AD, supporting a gut-brain axis in which T H 17 cells, induced in intestine-associated tissues, could drive neuroinflammation 76 and promote worsening of cognition 77

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