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In heterogeneous tumor environments, achieving selective targeting of mutant p53 cells without damaging wild-type p53-dependent normal cells is a major challenge, mainly for the following reasons: some drugs targeting mutant p53 may also be toxic to wild-type p53 cells, and the complex tumor microenvironment may affect the efficacy of drugs

A previous study demonstrated that in ASS1-deficient myxofibrosarcoma, ASS1 re-expression inhibited tumor growth by inhibiting tumor angiogenesis and inducing G1 phase arrest, indicating that ASS1 was a new tumor suppressor (Huang et al., 2013)

NASH nonalcoholic steatohepatitis a method of treating or preventing type 2 diabetes in a subject in need thereof comprising orally administering a therapeutically effective amount of the solid oral pharmaceutical composition according to any one of items 1 to 56 to the subject