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a , WT macrophages were incubated with LPS (100 ng/mL) in the presence or absence of 100 nM AP20187 for 20 hours

Caveolae Small, flask-like invaginations of plasma membrane that are abundant in many mammalian cell types including adipocytes

(Nature, 2014) used an antisense oligonucleotide to knock down NNMT in mice and reported reduced fat-mass gain, better glucose tolerance, and lower liver triglycerides the founding paper for the whole NNMT-inhibitor field