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This is characterized by reduced collagen content and diminished mechanical strength, contributing to increased plaque vulnerability.Under such conditions, plaque rupture or superficial erosion may expose thrombogenic components to the circulating blood, triggering platelet adhesion and activation as well as the coagulation cascade, leading to thrombus formation of varying extent

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87 Moreover, -alanine, a non-essential amino acid structurally similar to lactate, suppresses breast cancer tumorigenesis by competing with lactate for binding to AARS1 to interfere with p53 lactylation