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( ++ At least one of the required measures in the APP Plus quality measure set does not have a benchmark as described at 414.1380(b)(1)(i)(A)

For example, cell-free mtDNA is sensed by TLR9 in endosomes (recognizing CpG DNA) and by Cyclic GMP-AMP synthase (cGAS) in the cytosol (recognizing DNA in general), leading to production of inflammatory cytokines and interferons (1114)