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The ER membrane protein EI24 senses the elevation of H 2 O 2 levels in ER and facilitates the binding of RNA binding protein RNA transcription, translation, and transport factor (RTRAF) to the 3-untranslated region (UTR) of NOX4 messenger RNA (mRNA), inhibiting the translation of NOX4 and suppressing further H 2 O 2 production and redox damage [98], suggesting the self-regulation of ER ROS in maintaining oxidative homeostasis

These natural therapies have been shown to mitigate myocardial cell damage caused by MI through mechanisms such as oxidative stress, inflammation, apoptosis, angiogenesis, myocardial fibrosis, autophagy, endoplasmic reticulum stress, mitophagy, and pyroptosis

The collected platelets are then injected back into the injured area to stimulate healing and regeneration

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