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Patients vary greatly as to their ideal dose of hydroxyB-12 and how often (once a day up to four times per day) and whether best in AM or best in PM or whether both AM and PM

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o Novo Nordisk has shown strong confidence by advancing both subcutaneous and oral forms of amycretin into a comprehensive Phase 3 program (AMAZE) expected to start in Q1 2026 A Broader, Segmented Portfolio Approach: The company is now clearly articulating a more sophisticated strategy that goes beyond a simple "efficacy race." o Cagrilintide (monotherapy) is being advanced into a dedicated Phase 3 program (RENEW) in Q4 2025