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Herpesvirus infected cell cultures show an accumulation of protein carbonyls (i.e., protein oxidative damage) during the progress of infection, which is important since only a small fraction of carbonylated proteins are removed through proteasome-dependent proteolysis 16

The search keywords were inflammation, arthritis, gout, anti-inflammatory drugs, and NSAIDs. Studies providing relevant information for the present manuscript were included, whereas all other publications were excluded

*Correspondence: Martin Joyce-Brady, The Pulmonary Center, Boston University School of Medicine, 715 Albany Street, R304, Boston, MA 02118, USA e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology

Sanchez, J.-F., Hoh, F., Strub, M.-P., Aumelas, A