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1214 Wirkungen der genannten Biogenen Aminen Putrescin: Verstrkung der Histaminwirkung

ACN acetonitrile AcOH acetic acid Acp-OH 4-(2-aminoethyl)-1-carboxymethyl-piperazine Ado 8-amino-3,6-dioxa-octanoic acid Boc t-butyloxycarbonyl DBU1,3-diazabicyclo[5.4.0]undecene DCC N,N-dicyclohexyl carbodiimide DCM dichloromethane DIPEA diisopropylethylamine DMAP dimethylamino-pyridine DMF N,N-dimethylformamide DMSO dimethylsulfoxide EDC 1-Ethyl-3-(3-dimethylaminopropyl)carbodiimid EDTA ethylenediaminetetraacetic acid eq stoichiometric equivalent Fmoc 9-fluorenylmethoxycarbonyl HATU O-(7-Azabenzotriazol-1-yl)-N,N,N,N-tetramethyluronium hexafluorophosphate HFIP hexafluoroisopropanol HOBt N-hydroxybenzotriazole IS internal standard LCMS mass spectrometry-coupled liquid chromatography Lys lysine Mal 3-maleimido propionyl Mal-PEG6-NHS N-(3-maleimidopropyl)-21-amino-4,7,10,13,16,19-hexaoxa-heneicosanoic acid NHS ester MHA 6-mercaptohexanoic acid Mmt 4-methoxytrityl MS mass spectrum MW molecular mass n.d

The results of these in vitro studies suggest that elevated ROS facilitates the replication process in an array of viruses, including coronaviruses, especially in G6PD-deficient cells where the level of ROS is dysregulated [6, 38, 41, 42]

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