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Appreciate the strong engagement and industry discussion throughout the session

From the immediate ligation period, the increased intracranial (superior sagittal sinus) hypertension coincided with a consistently swollen brain, severe brain edema and congestion, large intracerebral hemorrhage in the fronto-parietal area, and intraventricular hemorrhage in the central and lateral ventricles

The ratio of postsynaptic mRFP--actin labeled spines juxtaposed to Synapsin or VGLUT1 spines was not different from control treated neurons suggesting treatment-induced spines are forming functional synapses (FIG

The Phase 2 retatrutide trial (PMID 37366315) reported -24.2% body weight change at the 12 mg weekly dose across 48 weeks