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FrisoniGBHanssonONicholsEGaribottoVSchindlerSEvan der FlierWMet al

YY2/PHGDH axis suppresses tumorigenesis by inhibiting tumor cell de novo serine biosynthesis

At week 15, rats were sacrificed to assess liver/body weight ratio, degree of liver fibrosis (Masons trichromic) and steatosis (oil red), and plasma endotoxin, IL1- and TGF- levels (ELISA) Results: All NASH rats increased in body weight, whereas liver/body weight ratio normalized in group 2