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The mitochondria are central to energy production in all cells and are affected by iron overload, leading to mitochondrial oxidative stress and participation in ferroptosis ( Recent studies have highlighted the role of mitochondrial calcium uniporters (MCU) in mediating iron-induced mitochondrial dysfunction

Mechanistic studies reveal that lipoic acid can inhibit ferroptosis by downregulating transferrin receptor expression and upregulating GPX4, thereby protecting neurons involved in learning and memory and improving cognitive function ( Figure 4 ) (190)

Modeling the reactions of superoxide and myeloperoxidase in the neutrophil phagosome: implications for microbial killing

BPC-157 + TB-500 is a synergistic combination of two synthetic peptides studied in experimental and scientific contexts