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Bridging butyrate and protein post-translational modification Studies have extensively investigated how butyrate mediates physiological effects by activating GPCRs and inhibiting HDACs

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142 Aloperine inhibits HMGB1/TLR4/NF-B and NLRP3 inflammasome activation, ameliorating oxidative stress and inflammation, thereby mitigating APAP-induced liver injury

This inherent heterogeneity underscores the necessity of adopting personalized approaches to understanding and targeting mitochondrial abnormalities in different cell types and tissues