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Colson et al., 2021

Due to the mediating position of the folate cycle between the two adjacent cycles, a folic acid deficiency has widespread consequences: the production of SAM falls, as does that of BH4 and the associated neurotransmitters

10.1210/jendso/bvab040 Maximilian Goebel, Russell K Brynes, David C Yau, Randall Y Chan, Sepehr Hamidi, Amy Alspach, Cynthia H Ho, Maria E Vergara-Lluri