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Another therapeutic approach with promising potential has been recently proposed by Wang and colleagues, who reported that significant elevation of IGF-1 levels could be achieved by combination treatment with tadalafil (TAD) and hydroxychloroquine HCQ

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Post-translational down-regulation of Nrf2 and YAP proteins, by targeting deubiquitinases, reduces growth and chemoresistance in pancreatic cancer cells

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Unfortunately, the widely held belief that it is safe for pediatric use is based on numerous clinical studies that assume that the liver is the target of drug toxicity [5]

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