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In cancer cells, GSH and enzymes of the mercapturic acid pathway play a role in resistance to many chemotherapeutic drugs

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For example, glutathionea powerful tripeptide antioxidantis completely broken apart by stomach peptidases into individual amino acids, losing its therapeutic glutathione form

Given the pivotal roles the pathophysiology and signaling pathways play in ischemic stroke, numerous therapeutic approaches have been explored in both experimental and clinical studies, and several of them have been demonstrated to be effective in treatment of ischemic stroke (Table 2)