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doi: 10.1006/geno.1995.9966 21 RamsdenDBWaringRHParsonsRBBarlowDJWilliamsAC

However, it is not always required for diagnosis

Minimally invasive procedures, such as a needle injection under image guidance, are used to introduce the cells into the IVD

Conditions such as pernicious anaemia (an autoimmune condition affecting intrinsic factor production, which should be confirmed with intrinsic factor antibody testing), Crohn's disease, coeliac disease, and those who have undergone gastric surgery (including bariatric procedures) may have severely impaired B12 absorption