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Posttranslational modification: natures escape from genetic imprisonment and the basis for dynamic information encoding

Collectively, these findings underscore the significant potential of iron chelators in the treatment of CNS diseases, highlighting their dual role in attenuating iron-mediated toxicity and providing neuroprotection via multiple signaling pathways

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In addition, there is a higher susceptibility of Nrf2 -null mice to liver injury [42], while the semi-synthetic oleanane triterpenoid compounds that activate Nrf2 were shown to be hepatoprotective in different models of liver disease (nonalcoholic fatty liver disease, acetaminophen-induced liver injury, and immune-mediated hepatotoxicity) that have been tested [40, 43,44,45]