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The TEM images showed that the Ag-NPs were in spherical shape and the average diameters of the particles were 3.20, 4.83 and 6.19 nm for the stirring times of 36, 48 and 72 h, respectively

40 The Nrf2/ARE pathway, by inducing antioxidant and anti-inflammatory responses, contributes significantly to the alleviation of oxidative stress and inflammation in the gut, thus playing a protective role in conditions like IBD

However, due to a lack of significant data, in Phase 1 and Phase 2 clinical trials, the manufacturer decided to stop further trials

These findings indicate that research in this field has garnered widespread attention in recent years, with increased mutual referencing and a trend of further development