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Systematic data describing how this feedback loop evolves across DR stages (non-proliferative versus proliferative) are also lacking, making it difficult to align potential interventions with the precise windows of the clinical disease course

In chloroplasts, the role of ascorbate has been proposed during breakdown of water in thylakoid lumen while in stroma to detoxify H 2 O 2 formed by the action of Fe-SOD and Cu/Zn-SOD (Gallie, 2012)

Hyde R, Taylor PM, Hundal HS

Emerging mechanisms: while ROS generation is well-established, recent research highlights more subtle, sub-lethal mechanisms: Autophagy modulation: ENMs like graphene oxide (GO) can induce autophagic flux blockade, where the accumulation of autophagosomes leads to cell death even in the absence of massive ROS