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British Journal of Sports Medicine 2013;47:649-653.

Apesar de mais de trs dcadas de investigao, uma reviso publicada em maio de 2026 concluiu que o desenvolvimento farmacutico da substncia permanece rudimentar: no h nenhuma formulao aprovada para uso clnico, um regime de dosagem validado ou ensaios clnicos de fase II concludos, alm de persistirem lacunas importantes sobre seu comportamento no organismo humano