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Dilda, Tumour Metabolism Group, Adult Cancer Program, Lowy Cancer Research Centre and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia e-mail: [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology

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Interestingly, it was found that the active Rac1, Cdc42, and RhoA not only affected the morphological plasticity of activated spines, but also could diffuse to nearby spines and lower the threshold of sLTP induction in these spines, a phenomenon typically referred to as heterosynaptic plasticity or synaptic crosstalk