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Indeed, inflammatory mediators (including glutamate) produced by reactive neuroglia can trigger intracellular signaling cascades that can alter mitochondrial metabolism including respiratory chain enzyme activity (this may explain increased lactate in the CSF of ME/CFS patients) (Shungu et al., 2012)

Biomimicking platelet-monocyte interactions as a novel targeting strategy for heart healing

Coleman MJ, Selmic LE, Samuelson JP, Jennings R, Huang PC, McLaughlin EM, Wavreille VA, Dornbusch JA, Lapsley J, Howard J, et al (2021): Diagnostic accuracy of optical coherence tomography for surgical margin assessment of feline injection-site sarcoma

It helps to define the two compounds up front