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In addition, the presence of the pro-inflammatory mediators, TNF and IL-1, also impair gut barrier integrity by activation of cell death pathways, such as apoptosis, thereby promoting elevated intestinal permeability (Ruemmele et al

doi: 10.2147/DMSO.S437865 22

An innovative FH-SSL-Nav liposome specifically targets the tumor matrix, facilitating infiltration, reducing ECM deposition, and enhancing blood perfusion (165)