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Description

8a) and pyramidal neurons in the CA1 region (red inset boxes in Fig

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The more severe stages, particularly mild cognitive impairment and dementia, often accompanied by progressive deficits, predominantly manifest in elderly individuals ( Insulin and Insulin-like Growth Factor receptors (IGF) receptors, akin to insulin-like peptides, are expressed in neurons and glial cells, with insulin receptor (IR), insulin-like growth factor 1 (IGF1R), and insulin-like growth factor 2 (IGF2R) signaling through their respective receptors well-expressed in regions such as the hippocampus, striatum, hypothalamus, cerebral cortex, and olfactory bulb (Wijesekara et al., 2018)

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Those are buccal or oral mucosal sites, not sublingual

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10.2174/1381612824666180712110447 101 SeiwerthS.SikiricP.GrabarevicZ.ZoricicI.HanzevackiM.LjubanovicD.et al (1997)

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