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Fendl et al., 2021

ALA possesses the unique ability to regenerate and recycle other depleted antioxidants back into their active states

BMJ 385 , e078378 (2024)

In addition, IL-6 regulates iron metabolism by activating the JAK-STAT3/BMP/SMAD pathway: after bone morphogenetic protein 6 (BMP6) binds to the membrane receptor, it induces phosphorylation of SMAD1/5/8 and upregulates hepcidin expression, resulting in the internalization and degradation of the iron transporter FPN, which exponentially increases the amount of intracellular iron accumulation, further exacerbating ferroptosis (228230)