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Microglial activation reduction: Retinal microglia (resident immune cells) become activated in disease states releasing inflammatory mediators and reactive oxygen species

However, we found no increase in expression in the presence of the ganglia compared to the mesenchyme alone (Fig 7D), suggesting that either other neuroattractants were being synthesized, that the epithelia produces these neuroattractants whether the nerves are present or not (i.e., the mesenchyme is supportive enough to maintain epithelial homeostasis) or that this phenomenon occurs earlier in culture (i.e., at an earlier stage when the nerves are just starting to envelop the epithelia) and any differences have been resolved by this later time point (day 7)