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Common cycling patterns include standard cycles of 8 weeks on followed by 4 weeks off, extended cycles of 12 weeks on followed by 6 weeks off for more aggressive protocols, and conservative cycles of 6 weeks on followed by 3 weeks off for those preferring a cautious approach

Lifestyle factors include a bad diet full of processed fats, heavy alcohol consumption, obesity, mental stress, and sleep deprivation

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In general, apoptosis of granulosa cells reduces the availability of hormones and survival factors that are essential for oocytes growth and maturation, impairing oocytes meiotic and developmental competence