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It also stimulates astrocytes and microglials, resulting in neuroinflammation

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In summary, the competition for shared substrates (H 2 O 2 , O 2 ) and the microenvironment-dependent activation barriers for different pathways collectively enable Pt nanozymes to perform context-aware redox regulation

The integration of these dual-layered signals provides a continuous picture from systemic metabolism to local renal injury, enabling the detection of molecular signatures of DKD even before the onset of albuminuria