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2.2.2 mRNA delivery RNA-based medicine has emerged as an alternative to DNA-based medicine due to technological breakthroughs such as the Nobel Prize winning development of nucleoside base modifications (111), which alongside other design features have endowed synthetic RNA constructs with greater stability and decreased immunogenicity (112)

This represented a 515% restriction relative to the standard average intake of control mice and was based on the measured food intake of 9-day ICV leptin-treated C3H/HeJ mice

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This is where L-carnitine enters the equation