glutathione persister cells

glutathione persister cells Drug-tolerant in head and neck squamous cell carcinoma: Molecular mechanisms and therapeutic opportunities Frontiers | Glutathione Peroxidase 4

Name: glutathione persister cells Drug-tolerant in head and neck squamous cell carcinoma: Molecular mechanisms and therapeutic opportunities Frontiers | Glutathione Peroxidase 4
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Frontiers Glutathione Peroxidase 4 as a Therapeutic Target for Anti Colorectal Cancer Drug Tolerant Persister Cells Glutathione synthesis: A two step pathway. Homeostasis of cellular Download Scientific Diagram Drug tolerant persister cancer cells are vulnerable to GPX4 inhibition PMC Targeting of vulnerabilities of drug tolerant persisters identified through functional genetics delays tumor relapse: Cell Reports Medicine

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PMID 3342239

A high GSH concentration and a reduced cellular state are known to promote self-renewal, allowing the GSH-to-ROS ratio to be a key determinant of cell fate (Zhou et al., 2016)

If the combined risk of multiple stressors needs to be assessed, the overall risk can be determined by superposition (total number of species affected by one or more stressors), resulting in a multi-stressor PAF (msPAF)