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Any negative side effects come from the very small risk of bleeding or infection after the shot

As an example of its importance in homocysteine metabolism, one study showedthat the addition of B12 to a folate regimen had a greater impact (7%) on homocysteine than did folate alone.*

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Both the 14 C and 13 C labeled absorption tests show promise but have not yet been developed for clinical tests, requiring further testing and validation (Brito et al., 2018)