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Zhang C, et al

Adaptive immune system in the pathogenesis of hypertension Studies identifying the role of the innate/adaptive immune system in the development of hypertension were performed in the 1980s, but reported conflicting results, which made it difficult to reconcile differences and decreased interest in this field

By contrast, ATF6 activation positively correlates with the severity of atherosclerotic lesion and accelerates plaque development by facilitating cholesterol accumulation (157)