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[PubMed: 3818895] 277

and C16A/C84A/C130A/C159A, a D1 disulfide and CSD deletant (Cerutti et al., 2014)

Furthermore, before considering SQOR-based therapies, it will be necessary to develop companion diagnostic tools to assess SQOR activity in a patients tissues and determine how dependent cell survival is on SQOR, thereby guiding whether to inhibit or activate SQOR to achieve the desired therapeutic outcome