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Griffiths and Flatters, 2015)

Similarly, the results of our present study demonstrate that catechol estrogens can strongly protect cells against chemically-induced ferroptosis through inhibition of PDI and subsequent abrogation of cellular NO, ROS and lipid-ROS accumulation 36

[373] claimed that chlorogenic acid is able to reduce DSS-induced colonic mucosal damage, by alleviating DSS-induced inflammation, oxidative stress, and apoptosis in the colon, while reducing ERK1/2, p -ERK, p38, p-p38, JNK, and p-JNK protein expression

The authors were able to show increased damage to mitochondrial DNA in both idiopathic PD and in patients carrying the G2019S LRRK2 mutation, and found that mitochondrial DNA damage correlated with LRRK2 kinase activity