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Ischemic models can be generated in both small and large animals

10.3390/biology9110363 94 HerrlingerK

J Hepatol 70:305313 Dinarello CA, Simon A, Van Der Meer JW (2012) Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

In a study involving HIF1 transgenic mice, DSS treatment led to an increase in the recruitment of M1 macrophages in wild-type mice, while mtROS production was elevated in HIF1 transgenic mice, inducing a shift of macrophages toward M2 polarization in the intestines [132]