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Glossary AIH autoimmune hepatitis AILI APAP-induced liver injury ALD Alcoholic liver disease APAP Acetaminophen ARE antioxidant responsive element ASH alcoholic steatohepatitis BS roccoli sprout BTB broad complex-tramtrack-bric-a-brac -TrCP -transducin repeats-containing protein BVR biliverdin reductase bZIP basic leucine zipper CCl 4 Carbon tetrachloride CMA chaperone-mediated autophagy CNC cap-n-collar ConA concanavalin A CTR carboxyl terminal region CUL3 CULLIN3 CYP cytochrome P450 CYP2E1 cytochrome P450 2E1 DGR double glycine repeat DILI drug-induced liver injury DMF dimethyl fumarate EMA European Drug Administration EpRE electrophile response element FDA Food and Drug Administration GSH reduced glutathione GSK-3 glycogen synthase kinase 3 HCC hepatocellular carcinoma HO-1 hemeoxygenase-1 HSC hepatic stellate cell ICC intrahepatic cholangiocarcinoma IVR intermediate region Keap1 kelch-like ECH-associated protein 1 LAMP-2A lysosome-associated membrane protein type 2A LSEC liver sinusoidal endothelial cell MMF monomethyl fumarate NAFLD non-alcoholic fatty liver disease NAPQI N-acetyl-1,4-benzoquinone imine NASH non-alcoholic steatohepatitis Neh1 Nrf2-ECH homology domain-1 NQO1 NAD(P)H: quinone oxidoreductase 1 Nrf2 nuclear factor-erythroid 2-related factor 2 PBC primary biliary cholangitis PSC primary sclerosing cholangitis ROS reactive oxygen species SFN sulforaphane sMAF small musculoaponeurotic fibrosarcoma oncogene homologue SOD superoxide dismutase TCM traditional Chinese medicines TP triptolide UDCA ursodeoxycholic acid

While there are no extensive RCTs data that discredit the association of irAEs with good clinical outcomes, a landmark analysis of a retrospective review of only 97 patients showed no difference in OS at 3 months in patients on single-agent ICI, even though the incidence of irAEs was associated with an OS (24.3 versus 5.3 months

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