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It was initially discovered in human plasma and is recognized as a signal peptide with remarkable repair and regenerative properties

Epithelial cells prime the immune response to an array of gut-derived commensals towards a tolerogenic phenotype through distinct actions of thymic stromal lymphopoietin and transforming growth factor-

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However, aggregated virions may still attach to some extent to target cells depending upon the nAb and assay conditions, and aggregation may affect a step downstream from viral attachment such as fusion or viral egress from infected cells (see below)