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Obesity Reviews, 17(3), 251-260

Forsyth et al., 1993) and methemoglobinemia in pediatrics (Geller et al., 2006)

A 2025 study in Biomolecules found that NNMT inhibitor treatment "reduces body weight, white adipose tissue mass, total cholesterol, and adipocyte size in obese mice." These changes suggest cardiovascular benefit beyond simple weight loss