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Together, these interconnected signaling cascades reshape transcriptional programs in fibroblasts, AECs, and endothelial cells, promoting myofibroblast differentiation, epithelial cell dysfunction, immune dysregulation, and excessive ECM deposition, which collectively drive the onset and progression of pulmonary fibrosis [33, 39] (Fig

To explore the lung regeneration process following successful fibrosis clearance, we mapped cellular profile by the scRNA-seq analysis of lungs between BLM+Saline and CD5/ LNP groups via the 10Genomics platform (Fig

Alleviation of hypoxia stress induced oxidative damage, endoplasmic reticulum stress (ERS) and autophagy in grass carp ( Ctenopharyngodon idellu ) by TTO ( Melaleuca alternifolia essential oil)

Why IGF-1 LR3 is more potent than native IGF-1 Native IGF-1 is largely sequestered in circulation by IGF binding proteins (IGFBPs) a family of six proteins that escort IGF-1 around the body and limit how much is free to engage receptors