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shows that 7nAChRs knockout mice that do not respond to cholinergic agonists, which in turn enhance the production of several cytokines and inflammatory markers, including tumor necrosis factor-alpha (TNF-) and interleukin-1 (IL-1) [65], this results from suppression of signal transduction cascade including PIK3/Akt and Nrf2 and upregulation of NF-B that represent a transcriptional factor capable of coordinating the inflammatory response, regulating the inflammatory gene expression [35, 66]

Pierre-Eugene C, Pagesy P, Nguyen TT et al (2012) Effect of insulin analogues on insulin/IGF1 hybrid receptors: increased activation by glargine but not by its metabolites M1 and M2

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